[MyoD mRNA expression in skeletal muscle of patients with myotonic dystrophy].

Xiaoping Zhao、Chuanqiang Pu、Feng Duan、Jie-Xiao Liu、Yanling Mao、Ping Luo

2009PubMedNeuroscience被引 1

摘要

OBJECTIVE: To explore the mRNA expression of MyoD gene in the skeletal muscles of myotonic dystrophy (MD) patients. METHODS: Muscle biopsy specimens were obtained from the biceps muscles of arm of 4 MD patients and 4 healthy controls. Semi-quantitative reverse transcription polymerase chain reaction was performed to evaluate the mRNA expression of MyoD in the specimens. RESULTS: The mRNA expression index of MyoD of the MD patients was (0.267 +/- 0.114), significantly lower than that of the healthy controls [(0.788 +/- 0.136), P = 0.001]. CONCLUSION: Down-regulated mRNA expression of MyoD gene is involved in the mechanism of DM.

引用本文（GB/T 7714）

Xiaoping Zhao, Chuanqiang Pu, Feng Duan, 等. [MyoD mRNA expression in skeletal muscle of patients with myotonic dystrophy].[J]. PubMed, 2009.

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