[RESEARCH PROGRESS OF OSTEOCLASTS FUNCTION BEYOND BONE RESORPTION].
摘要
OBJECTIVE: To review the osteoclasts (OC) function beyond bone resorption. METHODS: The related literature on OC function beyond bone resorption was reviewed, analyzed, and summarized. RESULTS: OC control the bone formation through releasing of matrix-derived growth factors, bidirectional cell-to-cell signals, and secreting OC-coupling factors, and play an important role in the niche formation, hematopoietic stem cells mobilization, and maintenance of its quantity and function; besides, OCs also regulate angiogenesis. CONCLUSION: These discoveries greatly enrich the current knowledge of OC function and open up an all-new research domain. However, the exact regulatory mechanism of OC affecting the hematopoiesis is still lack in-depth understood. Additionally, it remains to be elucidated how OC-coupling factors act on osteoblast lineage differentiation and how OC-induced angiogenesis participates in physiological and pathological processes. Unclosing the underlying mechanisms will facilitate providing scientific therapeutic strategies for treatment of many OC-related diseases.