[The different levels of prednisolone in perilymph after local and systemic treatment].
摘要
OBJECTIVE: The present study was to analysis the pharmacokinetics of prednisolone-21-hydrogensuccinate in the perilymph after local and systemic application. METHOD: On the local application, 5% prednisolone-21-hydrogensuccinate was directly applied into the round window niche under the microscopy. On the systemic application, the drug (60 mg/kg) was used intraperitoneal. Perilymphatic samples were obtained after variable periods of application. Levels of prednisolone-21-hydrogensuccinate in perilymph were measured by using HPLC. RESULT: The highest level of the drug was on (952.3 +/- 382.7) mg/L after 180 min. And remained on (18.72 +/- 16.97) mg/L after 960 min in the local application groups. In the systemic application group, the highest level of the drug was on(14.71 +/- 7.05) mg/L after 150 min. CONCLUSION: The results demonstrate that high levels and long time remain of prednisolone-21-hydrogensuccinate in perilymph are achievable by a single dose local application into the round window niche.