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[Blocking action of tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta].

Liu DLi GYilin Cao

1998PubMedMedicine被引 2

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摘要

OBJECTIVE: To investigate the effect of Tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta (TGF-beta). METHODS: The scar-derived fibroblasts were suspended in a solution of collagen matrix, and TGF-beta, they were associated to form a scar model in vitro. The influence of tetrandrine on the contraction indexes was observed. RESULTS: Tetrandrine plays a blocking action in the scar-collagen matrix contraction stimulated by TGF-beta, which was in a dose-dependent manner. CONCLUSION: This function of tetrandrine could be responsible for the anti-scar mechanism.

引用本文(GB/T 7714)

Liu D, Li G, Yilin Cao. [Blocking action of tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta].[J]. PubMed, 1998.

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