[Clinical analysis of amphotericin B in the treatment of invasive fungal infections in 121 patients with hematologic diseases].

Lin Jia、Mei Huang、Wenli Liu、Yicheng Zhang、Hanying Sun、Donghua Zhang、Deng Jinniu、Jianfeng Zhou

2008PubMedMedicine被引 1

摘要

OBJECTIVE: To observe the efficacy and safety of amphotericin B for treatment of invasive fungal infections (IFI) in patients with hematologic diseases. METHODS: 121 patients were given amphotericin B 5 -50 mg/d for 5 - 101 d with a median of 19 d. RESULTS: The clinical efficacy rate was 67.3%, and fungal elimination rate 66.7%. The adverse events included rigor and fever, hypokalaemia, hepatic damage, nephrotoxicity, nausea and vomiting, phlebitis and teeter. CONCLUSION: Amphotericin B is still a high-efficiency drug in the treatment of IFI, although it has many side effects. With monitoring of hepatic and renal function, it is still a relatively safe and effective drug.

引用本文（GB/T 7714）

Lin Jia, Mei Huang, Wenli Liu, 等. [Clinical analysis of amphotericin B in the treatment of invasive fungal infections in 121 patients with hematologic diseases].[J]. PubMed, 2008.

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