[A study of hemodynamic changes in the arteries of rabbit's eye caused by acute high intraocular pressure].
摘要
OBJECTIVE: Using the color Doppler flow imaging (CDFI) to measure and to study the hemodynamic changes of rabbit's retrobulbar artery caused by changes of intraocular pressure (IOP). To provide information for screening of drugs that improves the blood circulation and decrease the IOP. METHODS: This is a self-contrast research performed at the left eye: high IOP was induced, then the hemodynamic changes of rabbit's retrobulbar artery at different IOP stages were observed. RESULTS: Rabbit's ophthalmic artery (OA), ciliary artery (CA), short posterior ciliary artery (SPCA), central retinal artery (CRA) are low resistant artery. When the IOP raised rapidly, the velocity of blood flow became slower and resistance force index became higher. The hemodynamic changes could not return to normal even after the IOP decreased to the normal level. CONCLUSION: A short-term high IOP can influence the hemodynamic pattern of retro-bulbar arteries. Color Doppler flow imaging is a valuable method for monitoring these changes.