[Research on anti-thrombosis effect of ethanol extract from beheaded leech (EEBL)].
摘要
OBJECTIVE: To study the anti-thrombosis effect of EEBL and its possible mechanism. METHOD: Using a thrombosis model induced by collagen-adrenaline in mice and an artery-vein bypass in rats. The effect of EEBL on erythrocyte membrane and thrombocyte membrane fluidity were measured by fluorescence polarization. RESULT: EEFL inhibited the thrombosis induced by collagen-adrenaline in mice and the thrombosis in artery-vein bypass in rats significantly. EEBL also enhanced in vitro erythrocyte membrane fluidity and thrombocyte membrane fluidity markedly. CONCLUSION: The anti-thrombosis effect of EEBL may possibly be associated with the enhancement of fluidity of erythrocyte membrane and thrombocyte membrane. There exist anti-thrombosis chemical constituents in the body of beheaded leech.