[The effects of sodium pyruvate Ringer solution on hemodynamic and organ functions during shock stage in dogs with a 50% total body surface area full-thickness burn].
摘要
OBJECTIVE: To compare the effect of intravenous resuscitation with sodium pyruvate (Pyr) Ringer solution against lactated Ringer solution on hemodynamic and organ functions during shock stage in dogs with burn. METHODS: 28 Beagle dogs were subjected to 50% total body surface area (TBSA) burn, and they were divided into three groups: burn injury without fluid resuscitation (NR, n=8), Ringer lactate solution (RL, n=10), and Pyr Ringer solution (RP, n=10). They were given intravenous fluid resuscitation according to Parkland formula 30 minutes after burn. The hemodynamics, organ functions and mortality were observed in conscious state before burn injury, and 2, 6, 8, 12, 24 hours after burn injury. RESULTS: Within 24 hours after burn, all the dogs in NR group died, and those in RL and RP groups were all alive. At 2 hours after burn, the mean arterial pressure (MAP), cardiac index (CI), dp/dt max of left ventricular contractility were significantly reduced in NR, RL and RP groups compared with those before injury (MAP: 45.33±7.78 mmHg vs. 141.67±5.98 mmHg, 91.33±10.25 mmHg vs. 142.33±6.16 mmHg, 98.67±9.54 mmHg vs. 142.83±5.47 mmHg; CI: 8.17±0.83 mL×s(-1)×m(-2) vs. 48.34±3.33 mL×s(-1)×m(-2), 16.84±2.17 mL×s(-1)×m(-2) vs. 47.34±1.67 mL×s(-1)×m(-2), 19.00±1.50 mL×s(-1)×m(-2) vs. 47.34±1.33 mL×s(-1)×m(-2); dp/dt max: 426.83±51.91 mmHg/s vs. 1 372.50±39.61 mmHg/s, 594.00±88.23 mmHg/s vs. 1 363.83±44.92 mmHg/s, 645.00±66.82 mmHg/s vs. 1 395.83±19.49 mmHg/s, all P<0.05), and the systemic vascular resistance (SVR) and alanine transaminase (ALT), creatinine (Cr), serum MB isoenzyme of creatine kinase (CK-MB), diamine oxidase (DAO) were significantly higher (SVR: 1 322.50±36.37 kPa×s×L(-1) vs. 281.45±8.84 kPa×s×L(-1), 777.50±41.84 kPa×s×L(-1) vs. 289.72±6.70 kPa×s×L(-1), 571.40±40.01 kPa×s×L(-1) vs. 286.27±8.66 kPa×s×L(-1); ALT: 89.50±4.11 U/L vs. 40.57±3.63 U/L, 89.25±4.88 U/L vs. 37.92±2.62 U/L, 86.30±5.61 U/L vs. 38.47±3.50 U/L; Cr: 75.62±4.61 μmol/L vs. 41.58±2.78 μmol/L, 77.