Parameter optimization of temperature field in RF-capacitive hyperthermia
摘要
To realize a certain target temperature distribution in tumor tissues and avoid over-heating in normal tissues in radio frequency (RF)-capacitive hyperthermia, an objective function and some weight coefficients are introduced. Then using the 2-D finite element method, the electromagnetic and bio-heat transfer equations are solved, and using the genetic algorithm the heating configurations are recursively modified to minimize the objective function. Finally an optimum solution of the expected heating field distribution in hyperthermia is achieved. And with a human heterogeneous tissue model extracted from X-ray CT images, satisfactory optimization results are obtained in the simulations on a biplate RF-capacitive hyperthermia device. This optimization technique for controlling the body temperature field has shown scientific importance and practical values in the research of hyperthermia.