Influence of pH Environment on Nasal Absorption of Meptazinol Hydrochloride
摘要
AimTo investigate the relationship between p H environment of meptazinol hydrochloride (MEP) and its nasal absorption. MethodsIn situ nasal perfusion was performed to study the ef fect of pH environment on the nasal absorption. Its effect on the transport from nose to brain was further researched by in vivo experiment. Resu ltsIn in situ perfusion experiment, the nasal absorpti on of ME P in basic environment was significantly higher than that in acid condition, but the difference was not observed in in vivo experiment. Conclusio nThe pH environment of meptazinol hydrocloride in formulation canno t be regarded as an important factor influencing nasal absorption and transport from nose to brain.
引用本文（GB/T 7714）
Zhenqi Shi. Influence of pH Environment on Nasal Absorption of Meptazinol Hydrochloride[J]. 未知来源, 2004.
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