[Quantitative study on the expression of mRNA for TGF-beta and collagenase (MMP-1), tissue metalloproteinase inhibitor-1 (TIMP-1) in hypertrophic scar].
摘要
OBJECTIVE: To investigate the expression of mRNA for TGF-beta, MMP-1 and TIMP-1 and their effects on the formation of hypertrophic scar (HTS). METHODS: In situ hybridization and image analysis were used in this study. RESULTS: The expressions of mRNA for TGF-beta and TIMP-1 in HTS was greatly increased compared with those of normal skin. The average integral optical density of mRNA for TGF-beta and TIMP-1 increased by 8 and 7 folds (P < 0.001) related to normal skin and the expression of them showed highly positive correlation. CONCLUSIONS: The findings suggest that TGF-beta promotes the expression of TIMP-1 and may be a possible factor for hypertrophic scar formation.
引用本文（GB/T 7714）
Jiang Wu, D Chen, Wu Z. [Quantitative study on the expression of mRNA for TGF-beta and collagenase (MMP-1), tissue metalloproteinase inhibitor-1 (TIMP-1) in hypertrophic scar].[J]. PubMed, 2000.
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