[Association between polymorphism in DVWA and IL-1beta and Kashin-Beck disease].

Min Y U、Xiong Guo、Xiao-Yun Gao、Jianghua Lai、Qianqian Tu

2010PubMedNursing被引 6

摘要

OBJECTIVE: To investigate the association between IL-1beta and DVWA gene and Kashin-Beck disease (KBD). METHODS: Peripheral genomic DNA were extracted from 105 patients with KBD and 98 healthy controls. PCR-RFLP were performed to detect SNP loci of IL-1beta gene and DVWA gene. RESULTS: The patients with KBD had significantly higher frequency of rs16944 (IL-1beta) locus (chi2 = 24.28, P < 0.001) and single allele frequency of rs16944 (chi2 = 5.683, P = 0.0171) than the healthy controls. There were no significant differences in genotype frequencies,single allele frequencies and haplotypes in rs4685241 and rs1143627 between the patients with KBD and the healthy controls. CONCLUSION: rs16944 (IL-1beta) is associated with KBD.

引用本文（GB/T 7714）

Min Y U, Xiong Guo, Xiao-Yun Gao, 等. [Association between polymorphism in DVWA and IL-1beta and Kashin-Beck disease].[J]. PubMed, 2010.

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