[Association of dendritic cell infiltration with prognosis and lymph node metastasis of renal cell carcinoma].
摘要
OBJECTIVE: To investigate the relation of dendritic cell (DC) infiltration to the prognosis and lymph node metastasis of renal cell carcinoma. METHOD: The tissue specimens were obtained from 69 patients with renal cell carcinomas, who were treated surgically from 1994 to 2000 in our hospital and followed up for over 2 years. ABC immunohistochemical method using S-100 protein antibody was employed to examine the tumor tissues and the DCs was counted. RESULTS: The patients showing no signs of tumor recurrence within 2 years postoperatively had significantly greater number of S-100(+) DCs in the tumor tissues than that of patients with recurrence in 2 years (61.3 +/- 14.7/mm(2) vs 31.4 +/- 11.6/mm(2)). The number of S-100(+) DCs of the group with lymph node metastasis was much lower than that of the group without the metastasis (28.8 +/- 10.4/mm(2) vs 62.6 +/- 13.5/mm(2)). CONCLUSION: The density of DC infiltration is closely related to the prognosis and lymph node metastasis, which may be used as a good indicator for prognostic assessment of renal cell carcinoma.