[Experimental study of Yishou tiaozhi tablet on inhibiting hyperlipemia and atherosclerosis].
摘要
OBJECTIVE: To observe the effect of Yishou Tiaozhi tablet on lipid-metabolism and aortic intimal atherosclerotic plaque coverage in rabbit's model of experimental hyperlipemia and atherosclerosis. METHODS: Thirty-two rabbits were divided randomly into four groups, group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of Yishou Tiaozhi tablet was fed to the group A every day; to the group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; to the group C, forage with cholesterol and lipid was fed; and to the group D, ordinary forage only. Biochemical parameters were measured and pathomorphological examination were carried out 6 weeks later. RESULTS: (1) Yishou Tiaozhi tablet obviously lowered the levels of serum TC, TG, AI, ApoB, LP (a), ox-LDL, HYP, plasma Ca2+, TXB2 and increased the levels of serum HDL-ch, ApoA1, ApoA1/APoB, plasma 6-keto-PGF1 alpha(P < 0.01). (2) Pathomorphological examination showed that in the group A aortic intimal atherosclerotic plaque area and arterial intima thickness obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not seen. CONCLUSION: Yishou Tiaozhi tablet can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.