The Structure Modifications and Functions of P6A
摘要
Peptide 6A (P6A), one of the products degraded from fibrinogen β chain, which can increase CPF and inhibit thrombosis significantly, is a potential thrombodasiser. In this paper P6A was selected as the lead compound and the residue Ala' was substituted. Thus the derivatives Lys1, Arg1, Asp1, Asn1, Glu1, Gin1 and Gly1-P6A were synthesized. The bioassay indicates that the substitution of amino acid with acidic or basic side chain at position 1 of P6A will decrease the vasodilatation of P6A and the substitution of amino acid with amide side chain at this position of P6A may increase the activity significantly.
引用本文（GB/T 7714）
Peng Shi, Xu Yu. The Structure Modifications and Functions of P6A[J]. 未知来源, 1994.
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