[Gene expression profile changes in oral verrucous carcinoma and oral squamous cell carcinoma].
摘要
OBJECTIVE: To determine the difference in the gene expression between human oral verrucous carcinoma (OVC) and oral squamous cell carcinoma (OSCC). METHODS: cDNA chip was used to detect the mRNA of cancer tissue from 4 OVC and 4 OSCC. After profile blotted and handled by bioinformation, the gene expression of these two kinds of lesions was examined. RESULTS: Using the BioStarH-40 profile, 593 different expression of genes was found. The rate of different genes was 15.2%, of which the expression of 283 genes increased (59 genes significantly increased) and 310 genes decreased (98 genes significantly decreased) in OVC tissue than that in OSCC. CONCLUSIONS: The gene expression of OVC and OSCC was different, which many contribute to the different biological behavior of these two kinds of lesions.