[Study of mutation and single nucleotide polymorphism of PDGFRbeta and SHIP gene in acute myeloid leukemia].

Sujiang Zhang、Jianyong Li、Jingyi Shi、Zhanzhong Shi、Bai-Wei Gu、Xuetao Bai、Yongmei Zhu、Zhixiang Shen

2006PubMedMedicine被引 1

摘要

OBJECTIVE: To investigate the significance of mutation and single nucleotide polymorphism (SNP) of class III receptor tyrosine kinases such as PDGFRbeta and SHIP in acute myeloid leukemia (AML) patients. METHODS: Screening of the mutation and SNP of PDGFRbeta and SHIP by genomic PCR, RT-PCR, directly sequencing and Mass-ARRAY system was carried out in 273 AML patients. RESULTS: The mutations of PDGFRbeta R685C and SHIP Q1153L were detected for the first time in AML patients. The positivity ratio was 0.73% and 0.36% respectively. CONCLUSION: The mutations of PDGFRbeta R685C and SHIP Q1153L may contribute to leukemogenesis of AML.

引用本文（GB/T 7714）

Sujiang Zhang, Jianyong Li, Jingyi Shi, 等. [Study of mutation and single nucleotide polymorphism of PDGFRbeta and SHIP gene in acute myeloid leukemia].[J]. PubMed, 2006.

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