[Changes of serum lipids after soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-beta genotypes].
摘要
OBJECTIVE: To observe the change of blood lipids after one-year of soy isoflavone and calcium supplementation in postmenopausal Chinese women with different ER-beta genotypes. METHODS: Sixty postmenopausal women with normal serum lipid levels but with bone loss or even osteoporosis were selected from Wuhan. The ER-beta genotypes of subjects were identified. The subjects were randomly divided into two groups, group I was given 440 mg/d calcium and VD 100 IU/d and group II was given calcium 440 mg/d, VD 100 IU/d and soy isoflavone 100mg/d for one year. Serum lipids, including TG, CHO, LDL and HDL were measured before and 12 months after intervention. RESULT: Total cholesterol was decreased both in group I and group II (P <0. 05). The change of serum TG was significantly different between group I and group II in subjects with Rr/rr genotype (0. 20 +/- 0. 41 and 0. 44 +/- 0. 93, P <0. 05). CONCLUSION: Rational intervention with calcium and soy isoflavone for postmenopausal women might be in favor of their health in bone and blood lipids metabolism, but the effects might be varied by different ER-beta genotypes.