[Preparation of gemcitabine polybutylcyanoacrylate nanoparticles].

Huang Le-song、Chunxia Wang、Zhiliang Chen、Jia Wan、Xiqing Yan、Gang Duan

2007PubMedMedicine被引 4

摘要

OBJECTIVE: To optimize the preparation process of gemcitabine polybutylcyanoacrylate nanoparticles (GCTB- PBCA-NP). METHODS: According to the particle size, the entrapment efficiency and the loading quantity of GCTB-PBCA-NP, single factor analysis was carried out to optimize the component composition and preparation process based on an orthogonal design. RESULTS: The mean particle size of the NP was (112-/+9) nm with an entrapment efficiency of (54.12-/+2.43)% and drug loading of (11.08-/+0.89)%. CONCLUSION: An optimized nanoparticular drug delivery system is obtained by emulsion polymerization.

引用本文（GB/T 7714）

Huang Le-song, Chunxia Wang, Zhiliang Chen, 等. [Preparation of gemcitabine polybutylcyanoacrylate nanoparticles].[J]. PubMed, 2007.

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