Pharmacokinetics of Scutellarin in Dogs
摘要
Aim To establish an RP HPLC method for the determination of scutellarin in plasma and study its pharmacokinetics in dogs. Methods Scutellarin was given to dogs by intravenous injection and determined by RP HPLC, the mean plasma concentration time curve was plotted and pharmacokinetic parameters were calculated by program 3p87. Results The concentration time curve of scutellarin could be fitted to three compartment model with T 1/2 pi, T 1/2 α and T 1/2 β being 1.05±0.80 min, 6.99± 2.76 min and 51.61±28.78 min, respectively, Vc being 880.1±508.3 mL, CL being 189.6±53.8 mL·min -1 , and AUC 0 90 and AUC 0 ∞ being 574.43±133.95 μg·min·mL -1 and 599.34±132.00 μg·min·mL -1 , respectively. Conclusion The fact that the concentrations of scutellarin in plasma declined rapidly after the medication suggested that the T 1/2 of scutellarin should be taken into account in drug administration and preparation development.