[Determination and pharmacokinetics of photosensitizer ZnPcS2P2 uptaken by K562 cells].

Baogang Xie、Huifang Huang、Jian‐Dong Huang、Naisheng Chen、Jinling Huang

2004PubMedMedicine被引 1

摘要

The di-sulfonated di-phthalimidomethyl phthalocyanine zinc (ZnPcS2P2) was an amphiphilic photosensitizer for photodynamic therapy of cancer. According to fluorescence analytical method, extracting efficiencies of 2.0% SDS (Wt%), 1.5% Triton X-100 (phi) and DMF for ZnPcS2P2 in K562 cells were compared. The results showed that 1.5% Triton X-100 was the most efficient reagent for the first time extracting. Using 1.5% Triton X-100 as extracting reagent, the kinetic curves of cellular uptake of ZnPcS2P2 as well as LDL-ZnPcS2P2 complex by K562 cells were determined. Compared with ZnPcS2P2, the maximum cellular uptake of LDL-ZnPcS2P2 by K562 was doubled, which indicated that LDL was an effective targeting delivery vehicle for ZnPcS2P2.

引用本文（GB/T 7714）

Baogang Xie, Huifang Huang, Jian‐Dong Huang, 等. [Determination and pharmacokinetics of photosensitizer ZnPcS2P2 uptaken by K562 cells].[J]. PubMed, 2004.

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