[Clinical analysis of combination therapy for 252 patients of lung cancer with brain metastasis].
摘要
OBJECTIVE: To evaluate the efficacy of combination therapy and prognostic factors for lung cancer patients with brain metastasis. METHODS: The survival time and survival rates with various therapeutic methods were analyzed retrospectively in 252 patients with brain metastasis. RESULTS: The median survival time and 1, 2 year survival rates in surgery and X-knife plus radio-chemotherapy group and combination therapy of radiotherapy with chemotherapy were significantly longer than radio-chemotherapy alone group (P < 0.01 and P < 0.05); the pathological type of lung cancer did not affect the survival time and survival rate (P > 0.05); the survival time and survival rate of single brain metastasis (median survival time was 8.5 months 1, 2 year survival rates were 35% and 11% respectively) and non-extrabrain metastasis (8.5 months, 29%, 8%) were much longer than multiple brain metastasis and extrabrain metastasis (P < 0.01); the 1 year survival rate of older patients(> or = 50 years, 29%) were significantly higher than younger ones (< 50 years, 15%) (P < 0.05). CONCLUSIONS: Combination therapy of surgery and X-knife plus radio-chemotherapy are better than radio-chemotherapy alone for brain metastasis of lung cancer, severity of metastasis and patients' age are the prognostic factors.