长链非编码RNAs的作用机制及其在肿瘤中的作用
摘要
Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs longer than 200 nucleotides in length. They are very important gene expression regulatory factors. They are involved in transcriptional regulation by changing the chromatin structure and modulating the activity of transcriptional factors, and also involved in post-transcriptional regulation by regulating the processing and translation of mRNA. Alterations in the expression level of lncRNAs associate with carcinogenesis, and some lncRNAs can trigger tumors which are highly expressed in tumors while some can prevent tumors which are expressed lowly. This review summarizes the latest developments of the researches on lncRNAs, and mainly introduces the moleculr mechanism and the relationship between the dysregulation of lncRNAs and carcinogenesis. This provides a new way for us to understand the function of lncRNAs and their relationship with malignant tumours.