青蒿琥酯对人白血病K562 细胞凋亡抑制蛋白表达的影响

2011Chinese Science Bulletin (Chinese Version)Biochemistry, Genetics and Molecular Biology被引 2开放获取

摘要

Western blot was performed to detect the influence of Artesunate on the expression of X-linked inhibitor of apoptosis protein (XIAP), survivin, cellular IAP1 (cIAP-1), and cellular IAP2 (cIAP-2), and to investigate the effect of Artesunate on caspase-3 and poly ADP-ribose polymerase (PARP) cleavage in human erythroleukemia K562 cells. Artesunate downregulated the expression of XIAP, survivin, and cIAP-2, and upregulated the expression of a 17-kD caspase-3 cleavage fragment and an 85-kD PARP cleavage fragment. By down-regulating XIAP, survivin, and cIAP-2, Artesunate induced apoptosis in K562 cells. The mechanism of this apoptosis may involve caspase 3.

引用本文（GB/T 7714）

Weiqin Wang, Yonggang Wang, Xiaohong Jin. 青蒿琥酯对人白血病K562 细胞凋亡抑制蛋白表达的影响[J]. Chinese Science Bulletin (Chinese Version), 2011.

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DOI：https://doi.org/10.1360/972010-2003

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