Epidemic Characteristics of Gout and Primary Hyperuricemia in Shandong Coastal Area: A Randomized Stratified Cluster Sampling Survey
摘要
BACKGROUND: Recent studies have found that hyperuricemia and gout are closely correlated with the occurrence and. development of diabetes, coronary heart disease, hypertension and cerebrovascular diseases. It is of significance to investigate their prevalence so as to find way of early interventions. OBJECTIVE: To determine the prevalence and risk factors of gout and hyperuricemia among residents above 20 years old in Shandong coastal area. DESIGN: A randomized, stratified cluster sampling survey. SETTING: Department of Endocrinology, Affiliated Hospital of Qingdao University Medical College. PARTICIPANTS: A random, stratified cluster sampling was conducted in Shandong coastal area including Qingdao, Yantai, Weihai, Rizhao and Dongying. Residents lived in these areas for 5 years or more, aged between 20 to 80 years, were selected, and they were surveyed by family as a unit. METHODS: A randomized, stratified cluster sampling survey was conducted. The prevalence of gout and hyperuricemia were investigated among about 5000 residents in Qingdao, Yantai, Weihai, Rizhao and Dongying. The serum uric acid, lipids, glucose and creatinine were detected with Sysmex chemix-180 total automatic biochemical analyzer. Those with uric acid higher than reference level were reexamined by collecting fasting blood sample on the third day. The comparison between rates was taken with the Chi-square test, means between two groups with the t test, means between multiple groups with analysis of variance, correlation between dependent and independent variables with logistic regression analysis. MAIN OUTCOME MEASURES: Prevalance of hyperuricemia; Level of serum uric acid; Prevalence of gout in patients with hyperuricemia; Influencing factor of hyperuricemia. RESULTS: This investigation planned to include 5 500 subjects while in fact 5 003 subjects were investigated and the response rate was 91%, in which males were 2395 (47.87%) and females were 2608 (52.13%). ① The prevalence of hyperu