Remission of Diabetes Mellitus after Switching from Clozapine to Risperidone
摘要
Background: Antipsychotic drugs such as clozapine are known to potentially cause metabolic syndrome. In some cases, switching to a different second-generation antipsychotic drug (SGA) has been reported to resolve the SGA-induced hyperglycemia. Case Report: We report a case of a 58-year-old woman Taiwanese patient with long-term schizophrenia who had experienced new-onset, clozapine induced type 2 diabetes mellitus during the preceding four months. We changed clozapine (100-200 mg/day) to ziprasidone (80 mg/day) for seven months, but the change failed to resolve her hyperglycemia. Subsequently, we switched ziprasidone to risperidone (4 mg/day) for one month, and she became nonmoglycemic (fasting blood glucose level, 92-100 mg/dL). Conclusion: In the case of this patient, the aggressive switching from one SGA to another one effectively resolved the antipsychotic drug-induced hyperglycemia. But clinical observations using a larger number of cases are needed to gain more knowledge in switching among SGAs.