Association between Obesity and Acute high-altitude Disease
摘要
BACKGROUND: The occurrence and severity of acute high-altitude disease (AHAD) are determined by the speed entering the highland, the altitude of highland and seasons. The association between obesity and AHAD has not been fully investigated. OBJECTIVE: To investigate the association between obesity and acute high-altitude in people exposed rapidly to the highland. DESIGN: Comparative observation. SETTING: Department of Cardiology, General Hospital of Chinese PLA and Department of Cardiology, Tibetan General Hospital of Chinese PLA. PARTICIPANTS: The experiment was conducted at the Department of Cardiology, General Hospital of Tibetan Military Area Command of Chinese PLA in August 2006. Totally 82 Henan subjects aged 28-45 years were selected from the male workers constructing the Qinghai-Tibet Railway and their managers with acute high-altitude exposure. They had never been to the highland before, and all agreed to the detection. METHODS: ①Every subject completed the AHAD self-report questionnaire at sea level and 12 hours end 24 hours after ascending high-altitude. The items in the questionnaire included symptoms of headache, gastrointestinal symptoms, fatigue or weakness, dizziness, and insomnia. Each symptom was graded from 0-3 with 0 as no symptoms, 1 as mild symptoms, 2 as moderate symptoms, and 3 as severe symptoms and a total score of 15. A score of 4 or more could by identified as AHAD. ②The height and body mass were measured to calculate the body mass (BMI). Those with BMI≥28 kg/m^2 served as the obesity group [n=39, mean age (35±8) years], and those with BMI of 18.5-23.9 kg/m^2 as the normal body mass group [n =43, mean age (35±8) years]. ③Arterial blood was taken to evaluate arterial oxygen saturation (SO2), arterial oxygen pressure (PaO2) and arterial carbon dioxide pressure (PaCO2) at baseline and 24 hours after ascending high-altitude. ④The measurement data was compared by t test. MAIN OUTCOME MEASURES: BMI, vital capacity of lungs, SO2, PaO2 and