The influence of Trichosanthin on the induction of IgE responses to ovalbumin under adjuvant—free condition
摘要
Trichosanthin(TCS) is a potent allergen in mice.It can reproducibly induce specific IgE responses in C57BL/6J mice without the help of adjuvant alum.TCS can bring out the IgE responses to ovalbumin(OVA),while OVA itself could not induce IgE responses to it .However,TCS only works when OVA immunization is given one day after TCS immunization.Either time lag in OVA immunization,or immunization of both antigens at the same time,or OVA immunization given first,all has no effect on the induction of IgE responses to OVA.Through analysis of the antibody specificity of hybridoma clones,it indicated that specific antibodies to TCS or OVA were secreted by independent B cell clones.The IgE antibldies showed no polyreactivity to different antigens.
引用本文（GB/T 7714）
Jiyongyong, Cuihongyang. The influence of Trichosanthin on the induction of IgE responses to ovalbumin under adjuvant—free condition[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 1995.
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