Effect of carnosine on the gastric secretion in rats
摘要
Iron plays an important role in metabolism and iron deficiency leads to various clinical abnormalities. One of the main causative factors of iron deficiency is the poor absorption of dietary iron. It is well established that the bioavail‑ ability of non‑heme iron is enhanced by vitamin C citric acid and the meat factor. However the factor associated with improving iron absorption in meat has yet to be identified. Thus we investigated the effect of carnosine a well‑ known neuropeptide on iron solubility. Pylorus‑ligated rats were sacrificed 6 h after carnosine administration and the gastric juice of each rat was collected and analyzed for volume pH acidity and pepsin activity. The results indicate that carnosine promotes gastric juice and increases pepsin activity and pepsin output and sug‑ gest that carnosine enhances iron absorption by increasing iron solubility.