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EFFECT OF CURCUMIN ON THEOPHYLLINE PHARMACOKINETICS IN RABBITS

Hui Ching、Shang-Yuan Tsai、Su‐Lan Hsiu、Pingping Wu、Pei-Dawn Lee Chao

2001中醫藥雜誌Biochemistry, Genetics and Molecular Biology被引 5

摘要

Theophylline is a widely used bronchodilator with narrow therapeutic index and undergoes extensive metabolism by CYP1A2. Curcumin is a natural polyphenol with various beneficial biological activities and was shown to be a potent inhibitor of CYP 1A2. The purpose of this study was to investigate the effect of curcumin on the pharmacokinetics of theophylline in rabbits. The result showed that curcumin only significantly increased the absorption half-life of theophylline from 0.20±0.02 h to 0.36±0.05 h, other pharmacokinetic parameters were not affected. It indicated that coadministration of curcumin delayed the onset of theophylline but would not result in the acute intoxication of theophylline.

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