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Enantiomeric Separation of Amino Alcohols by Ion-pair Chromatography

Ming MingHuaHuXiu XiuZhu

2001中国化学快报:英文版Chemistry被引 2

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摘要

Enantiomers of four amino alcohols were resolved by ion-pair chromatography with (+)-10-camphorsulphonic acid as chiral counter ion. Studies of the influence of the mobile phase composition, the solute structure and the mobile phase flow-rate on separation are presented. Under the optimized conditions, enantiomeric propranolol, norephedrine, metropolol and salbutamol were separated using dichloromethane -1-pentanol (97:3, v/v) as mobile phase on Lichrospher-100-DIOL column.

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Ming Ming, Hua, Hu, 等. Enantiomeric Separation of Amino Alcohols by Ion-pair Chromatography[J]. 中国化学快报:英文版, 2001.

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