Mononuclear Cell Factor--Interleukin-1 in Rheumatoid Arthritis
摘要
Connective (issue destruction including bone rcsorption arc salient pathological features of chronic inflammatory diseases such as rheumatoid arthritis. These processes arc in part related to the high level of collagenasc and PGE, present within the synovium and the synovial fluid Initial studies indicate that the fibroblastic cells cultured from rheumatoid synovium are the principal sources of collagenasc and PGE,. It is reasonable to assume that these cells arc derived from proliferation of cells present in the synovium prior to the initiation of inflammation. The mononuclcarccll factor (MCF) produced by monocytcs and macrophages from the blood, synovial fluid and pannus stimulates the production of collagenasc and PGE, by fibroblastoid synovial cells. MCF shares chemical and biological properties with IL-1. MCF/IL-1 appears to play a pivotal role in communication between immune and non-immunc cells during chronic inflammation, since lymphocytes and lymphocyte products lead to an increased production of MCF/IL-1 in the presence of antigen. MCF/IL-1 modulates the morphology, replication and responsiveness of synovial cells to hormones, as well as stimulating these cells to produce collagenasc and PGE, In addition. MCF/IL-1 is involved in the reparativc processes which also occur in rheumatoid arthritis