中国血友病B生物基因治疗研究状况
摘要
Hemophilia B, defected of clot factor FIX, is a strict X chromosome linked recessive disease. Hemophilia B is a very good model for gene therapy due to its simple molecular basis, typical clinical characters, easily carried by different gene vectors. Functional FIX protein can be expressed in different cells that provided the possibility of producing recombinant protein drug. Moreover, the existing reliable animal model of hemophilia B makes the research of treatment more convenience. Chinese contributed to the gene therapy by succeeding in hemophilia B gene therapy during the early 1990s. Here, we briefly reviewed the advance of the bio-therapy and gene-therapy of hemophilia B in China.
引用本文（GB/T 7714）
JinZhong Xue JinLun Chen, 京伦 薛. 中国血友病B生物基因治疗研究状况[J]. Chinese Science Bulletin (Chinese Version), 2009.
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