Development of the New antimalarial Drug Pyronaridine：A Review
摘要
This report outlines the structure scheme and development of a new antimalarial drug pryonaridine,which was synthesized from either 2-aminopyridine or pyridine.A series of in vivo and in vitro experimental studies and the assessment of toxicity revealed pyronaridine to be a promising agent against erybthrocytic stage of malaria parasites.It exhibited low toxicity and had no corss-resistance to chloroquine.Chlinical administration in malaria cases showed high efficacy and mild side-effects.In order to retard the development of resistance of Plasmodium falciparum to pyronaridine,a combination of pyronaridine/sulfadoxine/pyrimethamine was used in the treatment of chloroquine-resistant falciarum malaria in Hainan Province.Further in vivo test was carried out to monitor the sensitivity of Pfalciparum to this combined formula for 5 years(1986-1990)in Diaoluo area where chloquineresistant falciparum malaria was prevalent.Drug resistance was not demonstrated in this field study.