Tannin inhibits HIV-1 entry by targeting gp41

LinLUE、Shu-wenLIU、Shi-boJIANG、Shu-guangWU

2004中国药理学报：英文版Immunology and Microbiology被引 33

摘要

AIM: To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells. METHODS: The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA. RESULTS: Tannins from different sources showed potent inhibitory activity on HIV-1 replication,HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation. CONCLUSION: Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell.

引用本文（GB/T 7714）

LinLUE, Shu-wenLIU, Shi-boJIANG, 等. Tannin inhibits HIV-1 entry by targeting gp41[J]. 中国药理学报：英文版, 2004.

引文网络

参考文献与被引分析加载中…

本站仅收录题录与摘要供学习参考，全文版权归属出版方；如有侵权请联系我们删除。