8q24 translocations in blastic transformation of mantle cell lymphoma.

Wing Y. Au、Douglas E. Horsman、David S. Viswanatha、Joseph M. Connors、Richard Klasa、Randy D. Gascoyne

2000PubMedMedicine被引 42

摘要

We report four cases of blastic transformation of mantle cell lymphoma (MCL), cytogenetically characterized by 8q24 karyotypic abnormalities in addition to t(11;14), suggestive of c-myc deregulation. Three patients developed blastic disease in lymph nodes, peripheral blood and bone marrow, after one to seven years, and died after 1 to 3 months. One patient presented with blastic MCL and died after 15 months. We propose that c-myc activation may be another cell cycle deregulation event leading to aggressive transformation in MCL.

引用本文（GB/T 7714）

Wing Y. Au, Douglas E. Horsman, David S. Viswanatha, 等. 8q24 translocations in blastic transformation of mantle cell lymphoma.[J]. PubMed, 2000.

引文网络

参考文献与被引分析加载中…

本站仅收录题录与摘要供学习参考，全文版权归属出版方；如有侵权请联系我们删除。