Severe Hypoglycemia in Type 2 Diabetes: A Hospital-based Retrospective Study
摘要
Background and Purpose For patients with diabetes, severe hypoglycemia has a significant economic impact and adverse effect on quality of life. The aim of this study was to assess the incidence of and risk factors for severe hypoglycemia among patients with type 2 diabetes. Methods We eva-luated a cohort of 1195 patients with type 2 diabetes followed in the outpatient clinic of Mackay Memory Hospital, Taitung, Taiwan from January 1 through December 31, 2004. Medical records were retro-spectively reviewed for demographics, medical history, duration of diabetes, results of laboratory tests, and current diabetes therapy. We used univariate and multivariate logistic regression to determine risk factors for severe hypoglycemia. Results The overall incidence of severe hypoglycemia was 7.4%. Patients on insulin therapy had higher incidence than patients on oral hypoglycemic agents alone (17.8% vs. 6.3 % P < 0.001). Multiple logistic regression showed that the risk of severe hypoglycemia increased with older age (P<0.001), lower educational level (P =0.02), HbA1c level lower than 7.0 % (P<0.001), current insulin therapy (P<0.001), and impaired renal function (P = 0.01) Conclusion Older age, lo-wer educational level, HbA1c 7, current insulin therapy and impaired renal function are risk factors of severe hypoglycemia in type 2 diabetes. ( J Intern Med Taiwan 2006; 17: 73-77)