The Impact of Diabetes on the Lower Urinary Tract Dysfunction
摘要
Diabetes mellitus has reached epidemic proportion in Asia. The researches of lower urinary tract dysfunction in diabetes have received close attention in the last years. For decades, the main focus of diabetes associated lower urinary dysfunctions has been referred to diabetic cystopathy. In a traditional viewpoint, the voiding dysfunction of diabetes is attributed to the impairments of vesical afferents and afferents pathway. In fact, diabetes can affect the lower urinary tract function via the mechanisms of osmolarity diuresis, metabolic perturbation, microvascular damage and urothelial dysfunction in diabetes. The interaction of benign prostatic hyperplasia, metabolic syndrome and obesity on diabetic lower urinary tract dysfunction is another interesting issue for scientists. In this review, current knowledge about the pathophysiology and clinical presentations of lower urinary tract dysfunction in diabetes is discussed. Therefore, we could get forward to future research.