The Association of Age, Gender and Metabolic Factors with Gallstone Disease
摘要
Aims: To determine the association of age, gender, metabolic risk factors and gallstone disease in a Taiwanese population.Patients and Methods: We conducted a retrospective case-control study. Between October 2004 and December 2005, 3990 adults who underwent health examinations were enrolled in this study. Subjects with gallstone were diagnosed by ultrasound or by a history of cholecystectomy because of gallstone disease. Gender, age, abdominal girdle, blood pressure, and serum levels of triglyceride, glucose and β-lipoproteins were compared between individuals with and without gallstone disease. We defined metabolic syndrome according to the 2005 International Diabetes Federation criteria, with Asian modification. Multivariate logistic regression analysis was used to identify independent risk factors associated with gallstone disease in males and females.Results: After reviewing the medical records, 277 of 3990 individuals met the criteria of having gallstone disease (males: females = 153/2359 (6.5%): 124/1631 (7.6%)). Participants aged ＜ 20 years (n=8) or with a history of gallbladder polyps (n=560) were excluded, and a total of 3422 individuals were entered into the subsequent analysis. Patients with gallstone disease had significantly increased age, serum fasting glucose level, abdominal girdle and systolic blood pressure as determined by univariate analysis (all p values were ＜ 0.05). The association between metabolic syndrome and gallstone disease was not significant after adjusting for age and gender (OR: 1.23, 95% CI: 0.92-1.65). Multivariate logistic regression analysis revealed that older age (＞ 50 yr vs. ≤ 50 yr) was significantly associated with gallstone disease in both genders (OR : 2.47, 95% CI : 1.71-3.56 in males; OR : 2.52, 95% CI : 1.64-3.86 in females). Central obesity was significantly associated with gallstone disease in women (OR: 1.69, 95% CI: 1.12-2.53). Glucose intolerance was significantly associated with gallstone disease in men (OR： 1.82