Asymmetric Pictet-Spengler Reactions：Synthesis of Tetrahydroisoquinoline Derivatives from L-DOPA
摘要
The cis-l-substituted-6,7-dihydroxy-l,2,3,4-tetrahydroisoquinoline-3-carboxylic acid esters 3 can be obtained in a highly diastereoselective fashion through 1,3-induction Pictet- Spengler(P-S) cyclization of the L-DOPA (3,4-dihydroxyphenylalanine) methyl ester with aromatic or aliphatic aldehydes under acidic conditions. Their epimers 4 are also obtained as minor products.
引用本文（GB/T 7714）
YeWANG, ZhanZhuLIU, ShiZhiCHEN, 等. Asymmetric Pictet-Spengler Reactions：Synthesis of Tetrahydroisoquinoline Derivatives from L-DOPA[J]. 中国化学快报：英文版, 2004.
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