Glycosides from Roots of Cyathula officinalis Kuan
摘要
To search for new and bioactive compounds from traditional Chinese medicines, a new glycoside,3-O-[α-L-rhamnopyranosyl-(l-→3)-(n-butyl-β-D-glucopyranosiduronate)]-28-O-β-D-glucopyranosyl oleanolic acid (1), was isolated from the roots of Cyathula officinalis Kuan, along with 3-O-(methyl-β-D-glucopyranosiduronate)-28-O-β-D-glucopyranosyl oleanolic acid (2), 3-O-β-D-glucopyranosyl oleanolic acid (3), 3-O-β-D-glucuronopyranosyl oleanolic acid (4), 3-O-[α-L-rhamnopyranosyl-(l→3)-(β-D-glucuronopyranosyl)] oleanolic acid (5), 3-O-(β-D-glucuronopyranosyl)-28-O-β-D-glucopyranosyl oleanolic acid (6), 28-O-β-D-glucuronopyranosyl-(1→4)-β-D-glucopyranosyl hederagenin (7), 3-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl]-28-O-β-D-glucopyranosyl oleanolic acid (8), and 3-O-[β-D-glucopyranosyl-(1→2)-α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl]-28-O-β-D-glucopyranosyl oleanolic acid (9). The structures of these compounds were determined based on spectral and chemical evidence. The 50 per cent growth-inhibiting (GI50) of compounds 1 and 5 against MDA-MB-231(a human breast cancer cell line) was 3.44 × 10-4 and 4.66 × 10-4 mol/L, respectively.