[Sodium channel blocking effect of scorpion venom on cultured mouse myocardiocytes].
摘要
Myocardiocytes of mice were cultured. Action potentials were recorded with microelectrodes inside the cells. Scorpion venom from Buthus martensii Karsch 3.75 or 7.5 micrograms.ml-1 decreased the duration of action potential and all of the depolarization concerned parameters of myocardiocytes. The Vmax, TP, APA behaved apparently in a dosage-dependent way. Restoration happened after washing out. Tetrodotoxin 2.5 micrograms.ml-1 acted in a similar way. Nimodipine 3.0 micrograms.ml-1 led to a decrease in action potential duration. BaCl2 0.1 mmol.L-1 elongated the action potential duration, while decreased the parameters concerned with depolarization. These results indicate that the scorpion venom has Na+ channel blocking action.
引用本文（GB/T 7714）
Hongyan Qi, Gaolong Zhong, Lili Chen, 等. [Sodium channel blocking effect of scorpion venom on cultured mouse myocardiocytes].[J]. PubMed, 1993.
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