Chronic amiodarone remodels expression of ion channel transcripts in the mouse heart
摘要
AIM: The basis for the unique effectiveness of chronic amiodarone on cardiac arrhythmias is incompletely understood. The present study investigated the pharmacogenomics profile of amiodarone on genes encoding ion channel subunits. METHODS AND RESULTS: Adult male mice were treated for 6 weeks with vehicle or oral amiodarone at 30,90,or 180 mg·kg^-1·d^-1, Plasma and myocardial levels of amiodarone and n-desethyl-amiodarone in
引用本文（GB/T 7714）
Sabrina Lebouter, Aziza El Harchi, Céline Marionneau, 等. Chronic amiodarone remodels expression of ion channel transcripts in the mouse heart[J]. 中国药理学报：英文版, 2004.
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