An Efficient Synthesis of Cyclopeptides Bridged with Aliphatic-aryl Ether Bond
摘要
Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via SN2 reaction between bromoacetylated at N-terminal and the phenol -OH group in C-terminal Tyr residue. All the products were obtained in good overall yields and characterized by related analytic data.
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ZheLIU, GuiJeiTIAN, DeXinWANG. An Efficient Synthesis of Cyclopeptides Bridged with Aliphatic-aryl Ether Bond[J]. 中国化学快报:英文版, 2005.
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