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Studies on Structural Changes of Collagen in Silicosis

Liyu-Rui、Huxun

1994生物医学与环境科学：英文版Medicine被引 2

摘要

In order to provide scientific information on the prevention and treatment of silicosis,studies about changes of silicotic collagen in lungs were carried out.In this paper,we present experiments about the structural changes of collagen in silicotic lungs of rats and patients.These included clectron microscopy,circular dichroism and infrared spectroscopy studies of collaeen fibers.The results indicated that fibers of silicotic collagen were shorter in length.smaller in diameter and decreased in α-helix content,The Si-O-R-group and -OH group were found increased and -C-C-backbone shortened.The increase of -Si-O-R-group indicated that silica formed linking bridgen between collagens whih may be the cause of progressive enlargement of nodules.

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