2-［1-（2-吡啶）乙氧基］乙酸2-（芳氨基）乙酯类化合物的合成及对小鼠记忆能力的影响
摘要
OBJECTIVE To synthesize the 2-(arylamino) ethyl 2-[1-(pyridin-2-yl) eth-oxy] acetate and its effects for ability of memory in mice. METHODS The compounds of 2-(arylamino) ethyl 2-[1-(pyridin-2-yl) ethoxy] acetate (5a~5e) were prepared using 2-ethylpyridine, through the Whol-Ziegler reaction, Williamson reaction and esterification, and its effects for ability of memory in mice were studied by swimming maze test. RESULTS The mistake frequency in mice with large and small doses of 2-(phenylamino) ethyl 2-[1-(pyridin-2-yl) ethoxy] acetate (5a) were significantly decreased as compared with alcohol group, there were a significant different between two groups. CONCLUSION The compound 5a can facilitate the memory in mice.
引用本文（GB/T 7714）
刘鹤, 李明洙. 2-［1-（2-吡啶）乙氧基］乙酸2-（芳氨基）乙酯类化合物的合成及对小鼠记忆能力的影响[J]. 未知来源, 2010.
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