Unique Cyclin-Dependent Kinase (CDK) Inhibitors at the ATP-site
摘要
Control of the cell cycle could be applicable in new approaches for cancer chemotherapy. The cyclin-dependent kinases (CDK's) and their corresponding complexes with cyclins are regulatory enzymes for which we have discovered a novel small molecule series of inhibitors, with potencies in the nanomolar range and good selectivity for the CDK's versus other kinases. We will discuss structure-based drug design efforts with crystal structures of complexes with certain CDK's. Cellular effects and some preliminary examination of in vivo cancer efficacy by these inhibitors will also be discussed.
引用本文（GB/T 7714）
Li, Lin. Unique Cyclin-Dependent Kinase (CDK) Inhibitors at the ATP-site[J]. Acta Scientiarum Naturalium Universitatis Sunyatseni, 2001.
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