熊果烷-12-烯-2β，3α-二醇-28β-酸的合成与表征及抑菌活性的研究
摘要
The natural product pentacyclic triterpenoid compounds, ursolic acid, are widely distributed in nature and found there are varieties of antibacterial activities in ursolic acid. Ursolic acid can inhibit the growth of Staphylococcus aureus. Streptococcus, Bacillus subtilis, Escherichia coli, Proteus mirabilis, G(superscript +) and G(superscript -), and can inhibit the growth of the wool microspore bacteria. Therefore, in order to develop a potential antibacterial activities derivatives of pentacyclic triterpenoids, we take the natural product ursolic acid with antibacterial activities as the lead compound for modifying their structures in this paper. New ursane derivatives were synthesized through modification at C-2, C-3 of ursolic acid. The structures of the compounds were confirmed by IR, 1HNMR and HRMS, and the antibacterial activities of target compound was better than oxacillin and norfloxacin.