THE CYTOTOXIC EFFECTS OF CRUDE BILE ON HUMAN PANCREATIC CANCER CELL LINES
摘要
［1］Attili AF, Angelico M, Cantafora A et al. Bile acid-induced liver toxicity: relation to the hydrophobic-hydrophilic balance of the bile acids. Medical Hypotheses,1986;19(1) : 57 ［2］Levers C, Faso A, Bass BL. Acute effects of bile acids on the pancreatic duct epithelium in vitro. J Surg Res,1998;74(1) : 43 ［3］Yeo C J. Pancreatic cancer: 1998 update. J Am Coll Surg, 1998;187(4) : 429 ［4］Prat F, Chapat O, Ducot B et al. A randomized trial of endoscopic drainage methods for inoperable malignant strictures of the common bile duct. Gastrointest Endosc, 1998;47(1) : 1 ［5］Garner CM, Mills CO, Elias E et al. The effect of bile salts on human vascular endothelial cells. Biochemica Biophysica Acta, 1991;109(1) : 41 ［6］Shekels LL, Beste JE, Ho SB. Tauroursodeoxycholic acid protects in vitro models of human colonic cancer cells from cytotoxicity of hydrophobic bile acids. J Laboratory and Clinical Medicine, 1996;127(1) : 57 ［7］Baijal PK, Fitzpatrick DW, Bird RP. Comparative effects of secondary bile acids, deoxycholic and lithocholic acids, on aberrant crypt foci growth in the postinitiation phases of colon carcinogenesis. Nutr Cancer, 1998; 31(2) : 81 ［8］Martinez JD, Stratagoules ED, LaRue JM et al. Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation. Nutr Cancer, 1998;31(2) : 111 ［9］Cabral DJ, Small DM, Lilly HS et al. Transbilayer movement of bile acids in model membranes. J Biol Chem, 1987;26(7) : 1801 ［10］Lichtenberg D, Robson RJ, Dennis EA. Solubilization of phospholipids by detergents. Biochem Biophys Acta,1983;737 : 285 ［11］Ljubnncic P, Fuhrman B, Oiknine J et al. Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages. Gut, 1996; 39 (3) :475 ［12］Knyrim K, Paveletz N. Cell interactions in a bilayerof tumor cells. Virchows Arch, B Cell Path, 1997;25: 309