对甘肃回族、藏族、汉族人群CYP2C19基因多态性分析
摘要
Objective: To identify the genotype and allele distribution feature of cytochrome P450 2C19 (CYP2C19) in Chinese Hui, Zang and Han populations from Gansu area, and observe the effect of gender on genetic polymorphism of CYP2C19 in these populations. Methods: The CYP2C19 genotypes of the unrelated healthy Hui, Zang and Han population volunteers were assessed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: Six different CYP2C19 genotypes were determined in this study. There was no significant difference in their distribution between males and females, but significant difference among the three Chinese nationalities (P＜0.05). Conclusion: Nationality has significant effect on genetic polymorphism of CYP2C19 in Chinese Hui, Zang and Han populations from Gansu area, but gender has no effect.